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Evidence Evidence that CFS/ME patients are low in methylation cycle metabolites: B vitamin evidence In a small study of 58 chronic fatigue syndrome patients with a history of Epstein-Barr infection and B-cell immunodeficiency, 81% responded to folinic acid

B12 is critical for red blood cell production, which ensures your tissues receive enough oxygen

If you are experiencing such problems, in the first instance you should see your GP who will undertake a blood test, review your symptoms, and diagnose any deficiency, alongside any need for dietary changes, oral supplementation, or prescribed injections of vitamin B12

The evidence was derived from several types of exposure (plasma concentrations of B12 or its biomarkers, B12 intake from foods or supplements, and genetically determined high plasma vitamin B12)

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