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Inoperable PN was defined as a PN that could not be completely removed without risk for substantial morbidity due to encasement or close proximity to vital structures, invasiveness, or high vascularity

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Non-normally distributed data were expressed as median (IQR) and analyzed using non-parametric methods

Ethical principles of the study complied with the European Directive 010/63/E, the Law on Amendments to the Animal Protection Act (Official Gazette 37/13), the Animal Protection Act (Official Gazette 135/06), the Ordinance on the protection of animals used for scientific purposes (Official Gazette 55/13), Federation of European Laboratory Animal Science Associations recommendations and the recommendations of the Ethics Committee of the School of Medicine, University of Zagreb

FIGURE 2 To determine gene structure diversity, alignments of genomic sequences against CDS were carried out by the online GSDS analysis tool (Figure 2B)