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Amreddy N, Muralidharan R, Babu A, Mehta M, Johnson EV, Zhao YD, Munshi A, Ramesh R (2015) Tumor-targeted and pH-controlled delivery of doxorubicin using gold nanorods for lung cancer therapy

This starts with in vitro studies on various cell lines to determine cytotoxicity, followed by in vivo studies using animal models to evaluate systemic toxicity and establish safe dosage levels [39,49,56]

But escalating before your body adapts does not produce faster results

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