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In addition, 5hmC suppression induced by L2HG treatment is partially restored by DMF treatment (Fig

Finally, we discuss emerging strategies to interrogate and modulate this circuit using integrated omics, CRISPR-based screening, and pharmacological approaches, emphasizing the need for context-aware and temporally controlled metabolic interventions to enhance T cellbased immunotherapies in solid tumors

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Metformin: from mechanisms of action to therapies

However, to our knowledge, this is the first report on the pharmacological options for preventing/alleviating erythrocyte damage in cholestatic/cirrhotic patients so far
