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Fu K, Pan H

Now, however, it is recognized that these RBC contain a coagulum of hemoglobin which has separated from the membrane, often leaving an unstained non-hemoglobin-containing cell membrane (i.e., having the appearance of a bite removed from the cell)

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Elina Ghondaghsaz: Writing original draft (equal)

Early haematological response begins with reticulocytosis (increased production of immature red blood cells) typically by day 3-4 of treatment , particularly with injectable forms, though the full resolution of symptoms may take several weeks to months