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This cleavage ultimately leads to a caspase-dependent cell death, which can be prevented by pan-caspase inhibitor Z-VAD-FMK (Khairalla et al., 2015)

In cancer, there is an increase in metabolism along this pathway

10.3390/cells11193153 30 FrisinaR

Nicotinamide and EGCG reduce A accumulation and protein oxidation in aged 3xTg-AD hippocampal neurons Since intracellular A aggregates increase across the lifespan of the 3xTg-AD model in vivo [38], and in vitro [1] and a hallmark for brain aging and the progression of AD is protein oxidation, including tyrosine nitration [1, 39], we immunostained neurons for A accumulation and protein nitration and evaluated the effects of treatment with nicotinamide and EGCG

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