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These cells are essential for preserving lung homeostasis because they have the ability to develop into a variety of lung cell types, such as endothelial and alveolar epithelial cells (86)

These distinctions highlight that the mode of GSH depletion, i.e., via acute blockade of synthesis versus more gradual enhanced degradation, can differentially influence the oxidative stress response, secondary transcriptional programs, and systemic physiology

doi: 10.3389/fpls.2018.00597 60 HuC.NieZ.ShiH.PengH.LiG.LiuH.et al

Furthermore, this review points out the limitations of traditional antioxidant treatments, such as supplementation of direct antioxidants and enhancement of endogenous antioxidant defense network, and highlights the opportunities brought by new technologies, aiming to provide directions for future research in this field (Figure 1)