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CaiD is still postulated to be involved in racemization of d-carnitine, as CaiC was shown to activate d-carnitine by adding a CoA group to produce d-carnitinyl-CoA, which is then theorized to be converted to l-carnitinyl-CoA by CaiD (Bernal et al

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Accordingly, genetic manipulations interfering with DNA repair ( Ercc1 -/ , Xpd TTD/TTD ), nuclear envelope maintenance ( Lmna G609G/G609G , Zmpste24 / ), mitotic spindle assembly ( BubR1 H/H ) and radical scavenging mechanisms ( Sod1 / ) have been used to generated models of premature aging and senescence, [17] which are now widely employed when investigating the efficacy of senotherapeutics in healthspan and lifespan extension