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Additionally, the depletion of MnSOD (superoxide dismutase) in RPE cells triggered the Hsp70-linked ubiquitin-dependent cleavage of GPX4, exacerbating ferroptosis of these cells (89)

Additionally, cisplatin induced the expression of STAT1 in the cochlea while concurrently downregulating the expression of STAT3

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Nuclear factor erythroid 2-related factor 2 (Nrf2), a stress-inducible transcription factor, protects cells from ferroptosis by directly or indirectly regulating GPX4 protein content

doi: 10.3389/fonc.2020.00155 32 HoferFDi SarioGMusiuCSartorisSDe SanctisFUgelS