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Although plasma levels are typically in the micromolar range, epithelial surfaces (e.g., lungs) maintain high extracellular GSH concentrations to protect against inhaled oxidants, such as hypochlorous acid (HOCl) (11-14)
doi: 10.3389/fphar.2025.1519497 108 CaoPGanJWuSHuYXiaBLiXet al
It is possible the human trials never delivered enough intact peptide to the relevant tissue to reproduce the rodent effect, though this remains a hypothesis rather than a demonstrated cause of failure
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Pharmacokinetics of tetramethylpyrazine in rat blood and brain using microdialysis
