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Following diagnosis, the average life expectancy is 35 years

Asian J Androl (2019) 21(6):5659

In the rd10 mouse model, which exhibits rapid progression of retinal degeneration, a notable increase in the expression of several key proteins related to iron transport and storage, such as transferrin, ceruloplasmin, ferritin, and the transferrin receptor, was observed (215)

The scaling problem: Translating 5 mg/kg from mice to humans is complex
