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Description
Studies showed that even in euthyroid individuals (defined as a TSH level in the upper half of the normal range), advanced liver disease has been associated with increased conversion of fT4 to inactive metabolite-reverse-triiodothyronine (rT3) in the liver, at the expense of DIO1-mediated conversion to the active metabolite-fT3 [19,20,21]
This process catalyzes the first rate-limiting step in the KP
notably CKD is a leading cause of mortality worldwide
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