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Ma, et al
TRP channels are a diverse superfamily of cation channels, which can be activated by an extensive range of stimuli (57)
Disruption of the normal gut microbiota may lead to intestinal dysbiosis, barrier dysfunction, bacterial translocation, and excessive production of uremic toxins, including indoxyl sulfate (IS), p-cresyl sulfate (p-CS), and trimethylamine-N-oxide (TMAO), all of which are implicated in the variant processes of kidney diseases development (Chen et al., 2019)

A review of symptoms with benign joint hypermobility syndrome in children
doi: 10.1200/JCO.2005.07.757