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it neutralizes free radicals and maintains cellular homeostasis

By mitigating lipid peroxidation, protein oxidation, and DNA damage, antioxidants help preserve BBB permeability and prevent the infiltration of neurotoxic blood-derived substances into the brain [150,206]

15 Being a powerful antioxidant, glutathione plays a critical role in several metabolic pathways: DNA and protein synthesis, amino acid transport, enzyme activation, immune system function, scavenging free radicals eg hydrogen peroxide, cofactor in Phase I cytochrome P450 enzyme-mediated detoxification, amino acid translocation across cell membranes, detoxification of xenobiotics, maintenance of sulfhydryl groups of proteins, mitochondrial function and maintenance of mitochondrial DNA, catalysis of exchange reactions and many more

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These patients also had higher pH ( P = 0.0223), O 2 pressure ( P = 0.0028), CO 2 tension ( P = 0.0309) and O 2 saturation ( P = 0.0123), compatible with the fact that SEV patients were intubated with mechanical ventilation