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Description
Usually, the needle should be inserted into the skin at 90 degrees (straight up and down, relative to the skin) to ensure that the medication is injected into the fatty tissue

Patients with severe heart failure or arrhythmias require monitoring because rapid shifts in free-fatty-acid metabolism can influence myocardial substrate utilization

doi:10.1111/andr.12805
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Significant joint pain, persistent numbness or tingling, or notable changes in blood glucose warrant reassessment
