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In the blood samples, free carnitine, interleukin-6, tumor necrosis factor-, C-reactive protein and IGF-1 were determined

More recently, a family of potent and highly selective mechanism-based suicide substrate inhibitors were developed and shown to promote the irreversible inhibition of gut microbiotadependent generation of TMA, suppression of host TMAO levels, and, in parallel, inhibition of platelet hyperresponsiveness and thrombosis potential in animal models (22)

SLOS patients display multiple anatomic aberrations and intellectual disability, although the phenotype of this syndrome is very diverse