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Notably, the variability of DNA methylation in the hippocampus is higher than in the cortical regions, which may be closely related to the severe neuronal damage in the hippocampus (229, 230)

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These concepts are fields of science that seek to understand the mechanisms underlying the effect and potential application of diet for the modulation of specific neurobiological pathways, the use of selected nutraceuticals to correct nutritional deficiencies, and the effects of the quality of various nutrients on mental health [8, 9]

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In hypoxic tumor microenvironments, hypoxia inducible factor 1 subunit alpha (HIF1A, also known as HIF1) represses DLAT expression and confers resistance to cuproptosis 176 , supporting the existence of a HIF1A-DLAT-GSH regulatory axis