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This effect of RRM1 silencing on erastin2-induced ferroptosis was specific: RRM1 silencing did not inhibit cell death in response to several mechanistically distinct small molecule inducers of apoptosis or other forms of non-apoptotic cell death that are not directly linked to intracellular GSH metabolism (Ko et al, 2019) (Fig S4A)

Importantly, these effects were achieved even though treatment was not initiated until 18 mo of age

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Abbreviations ALS: Amyotrophic lateral sclerosis 5-AVA: 5-Amino valeric acid c-fos: Proto-oncogene, the human homolog of the retroviral oncogene v-fos encoded in humans by the FO S gene EEG: Electroencephalogram fEPSP: Field excitatory postsynaptic potentials GABA: -Aminobutyric acid Glu: Glutamate Gln: Glutamine GS: Glutamine synthetase KA: Kainic acid Li-Pilo: Lithium-pilacarpine lTLE: Lateral temporal lobe epilepsy MeAiB: Methyl-amino-isobutyric acid MSO: Methionine sulphoksymine mTLE: Mesial temporal lobe epilepsy TLE: Temporal lobe epilepsy SE: Status epilepticus Pilo: Pilocarpine PTZ: Pentylenetetrazole References Baulac M, De Grissac N, Hasboun D, Oppenheim C, Adam C, Arzimanoglou A, Semah F, Lehricy S, Clmenceau S, Berger B (1998) Hippocampal developmental changes in patients with partial epilepsy: magnetic resonance imaging and clinical aspects

10.3390/nu16244296 291 TianK.-M.LiJ.-J.XuS.-W