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The characteristic structural motifs of the S100-gene family are two EF-hands, comprised of a helix-loop-helix unit, that are able to bind bivalent ions like calcium and zinc

To understand the molecular mechanisms of BV2-metformin-loaded PLGA on midbrain tissues, transcriptomic analysis using RNA sequencing was conducted

Michl P, Ramjaun AR, Pardo OE, et al

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2003 Oct;26(10):950-5