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doi: 10.1016/j.jocn.2004.05.019 103 WuDChenQChenXHanFChenZWangY

This is also common in people taking medications like Proton Pump Inhibitors (PPIs) or metformin , which can block the absorption of B12 and other B vitamins

Additional cell adhesion molecules considered part of the endothelial glycocalyx include the intercellular adhesion molecules (ICAM), platelet endothelial cell adhesion molecule (PCAM) and vascular cell adhesion molecule (VCAM), which are glycoproteins with important functions associated with inflammatory processes

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That decline correlates with slower wound healing, thinner skin, and reduced regenerative capacity