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External factors that contribute to the production of free radicals include smoking, environmental pollutants, radiation, drugs, pesticides, industrial solvents, and ozone (Gven et al

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Interleukin-1 receptor-associated kinase 1( IRAK-1 ) is a key downstream molecule of the TLR4 pathway, and its phosphorylation can activate a series of inflammatory pathways (84, 85), but in experiments, it was detected that CGA down-regulated the expression of TLR4 in the liver of mice exposed to ConA, and inhibited IRAK-1 , NF-B, and mitogen-activated protein kinase ( MAPK )

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