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Another study linked type 2 diabetes-associated variants in MAP3K5 to transcriptomic changes in human islets under stress, suggesting that genetic risk factors can predispose beta cells to dysfunction in response to metabolic and inflammatory challenges [20]

Appl Environ Microbiol 59(5):16711674 Chassaing S, Collin F, Dorlet P, Gout J, Hureau C, Faller P (2012) Copper and heme-mediated Abeta toxicity: redox chemistry, Abeta oxidations and anti-ROS compounds

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Duffield AJ, Thomson CD