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STERILE INFLAMMATION AND APAP HEPATOTOXICITY The extensive cell necrosis after an APAP overdose leads to release of damage-associated molecular patterns (DAMPs) including mitochondrial DNA, nuclear DNA fragments, high-mobility group box 1 (HMGB1) protein, and many others108110 (Fig
An increasing number of studies corroborate the pivotal role of oxidative stress in both the etiology and pathogenesis of metabolic syndrome [151,152]
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J Insect Physiol 58:220227
Key MN, Szabo-Reed AN
