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Current areas of scientific investigation include melanocortin receptor binding studies, GPCR signaling pathway analysis, neuropeptide signaling investigations, receptor selectivity research, intracellular signaling cascade studies, and signal transduction pathway analysis

13 found that during inflammation, the SREBP cleavage activating protein (SCAP)-Sterol regulatory element binding protein 2 (SCAP-SREBP2) complex, an important cholesterol receptor, promotes the activation of the NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome, thereby linking cholesterol synthesis to inflammatory signaling, which together promote macrophage activation and inflammation

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This does not necessarily mean that small polar molecules (like water) never enter the core of the bilayer, but if they do, they exit again quickly