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Cytosine DNA methylation is present in some Clade I nematodes 108,109,110 and siRNAs may lead to DNA methylation and transcriptional repression of mobile elements

No completed randomized controlled human trials exist for any indication as of 2026
Cats with LC have a variable prognosis,3, 6 likely a result of being diagnosed at different stages of a chronic disease process

Ji Y, Fioravanti J, Zhu W, Wang H, Wu T, Hu J, Lacey NE, Gautam S, Le Gall JB, Yang X, Hocker JD, Escobar TM, He S, DellOrso S, Hawk NV, Kapoor V, Telford WG, Di Croce L, Muljo SA, Zhang Y, Sartorelli V, Gattinoni L

Projected approval path: If Phase III trials confirm safety and effectiveness, Cagrilintide will likely be submitted for regulatory approval as a prescription obesity treatment in the next few years
