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This in turn permits to increase the diffusion of Pt ions and reverts platinum drug resistance 93

Experimental evidence using a high-iron diet demonstrated that increased iron levels favored Tfh and GCB cell expansion, enhanced secretion of inflammatory cytokines IFN- and IL-17A by CD4 + T cells, promoted autoantibody production in MRL/lpr lupus mice, and worsened their disease phenotype

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ALA can also increase the phosphorylation of AMPK and SREBP-1 C in the liver

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