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This paper demonstrates that resting metabolic rate is reduced in mice lacking orexin neurons
These metabolic changes can limit the work capacity of skeletal muscle, since the accumulated acetyl-CoA inhibits the activity of pyruvate dehydrogenase [64]
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Excluding the few exceptions where methionine may act as a redox sensor (e } : CS1 maint: multiple names: authors list (link) "Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age"
These abnormalities are well-documented in fibromyalgia patients
