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In the APAP hepatotoxicity-mediated immune response, KCs form the first line of defense by recognizing necrotic hepatocytes caused by drug injury through DAMPs, and KCs, upon activation release of cytokines such as IL-6, IFN, TNF and chemokines to regulate hepatocyte function

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Several studies as reported by Tan et al

[47] Peptide-based Therapy against Pro-inflammatory Cytokines/Chemokines Since pro-inflammatory cytokines and chemokines play a critical role in the pathogenesis of many autoimmune diseases, peptide-based vaccines have been designed to antagonize the pro-pathogenic cytokines and chemokines to reduce inflammation and tissue damage

[DOI] [PMC free article] [PubMed] [Google Scholar] (612).Dias SL