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aeruginosa and other bacterial pathogens are present in nearly all CF patients, with widespread biofilm formation ( 8.2 Summary of RCTs Early studies using low-dose NAC (200 mg TID) showed no significant benefit over placebo in PEFR, weight, antibiotic use, cough, sputum viscosity, or symptom perception ( 1 decline over 12 weeks, unlike placebo ( Two randomized trials reported significant improvements in FEV 1 and FVC with NAC (200 mg TID or 400 mg BID) in CF patients, with or without P

doi:10.1016/j.redox.2018.09.019

Available at: Mayo Clinic