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Mechanisms that reshape interneuron-to-RGC signals Although signals from ACs and BCs are rapidly altered following RGC axon injury and become critical regulators of neuroprotection and axon regeneration, these interneurons do not extend processes into the optic nerve, where injury to RGC axons occurs

Much of the human data is therefore older, and the compound never accumulated the kind of modern, well-controlled trials that would settle the question

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This review focuses on the application of nasal delivery of drugs using CPP-based systems based on our current understanding of how CPP can be applied in vivo delivery of peptide drugs through the nasal epithelium and of the potential advantages of the nasal administration route in systemic and brain drug delivery