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doi: 10.1016/S0015-0282(00)01720-9

Structure assignment revealed several key metabolic sites and diverse biotransformation pathways, including ester hydrolysis, aldehyde reduction, aldehyde oxidation, hydroxylation (monohydroxylation and dihydroxylation), glucuronidation, and the cross-combination of these pathways

Methods In this phase 3a, double-blind, randomized, placebo-controlled trial conducted in 12 countries, we assigned adults with a body-mass index of 27 or more, a glycated hemoglobin level of 7 to 10%, and type 2 diabetes in a 3:1 ratio to receive once-weekly cagrilintide-semaglutide (2.4 mg each) or placebo, along with lifestyle intervention, for 68 weeks