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Although therapeutic options are available for chronic pain and depression, less than 50% of all patients treated for chronic pain report a clinically meaningful (i.e., 50%) pain relief with current analgesic treatments, and only about 5060% of patients with major depressive disorders achieved remission after an adequate course with conventional antidepressants

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Of all the potential risk factors in idiopathic male infertility, the greatest importance is attributed to increased oxidative stress and altered levels of trace elements (118, 145147)

However, it is crucial to mention that the overall scientific evidence remains inconsistent

doi:10.1089/acm.2006.12.857