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Regulation of ferroptotic cancer cell death by GPX4

10.1172/JCI129317 J Clin Invest

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It has been reported that by inhibiting phosphorylation of serine 10 in this pathway, breast cancer cells simultaneously challenged with estradiol show an overproduction of ROS, with increased oxidation of the DNA that overwhelms the repair apparatus and triggers PCD in a great percentage of these cells 144 (Fig