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According to the classical paradigm of neurodevelopment, the central nervous system originates from the neural tube, whereas the peripheral nervous system primarily derives from the neural crest, reflecting distinct developmental lineages

Furthermore, upregulation of the PI3K/AKT/mTOR pathway is involved in the neuroinflammation and neuronal autophagy of ASD [29, 60]

However, limited studies show that the success rate may be lower than 30%

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The SCN clock entrains to the light-dark cycle and then coordinates the timing, or phases, of tissue clocks located throughout the brain and body 1,2