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The figures mentioned here are reflective of the date of writing and may be subject to adjustment

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True detoxification is a cellular process

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For adherent cells, gently detach cells from the substrate on which they are growing using a suitable dissociation reagent such as Gibco TrypLE reagent

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A highly reducing environment is maintained in subcellular compartments, e.g., the cytosol, nucleus, mitochondrial matrix, and peroxisome, to facilitate proper protein folding and activity

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Current strategies to combat this include not only modification of the AAV capsid and optimization of the viral genome, but also the use of immunosuppressive therapy [153]

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