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The figures mentioned here are reflective of the date of writing and may be subject to adjustment

True detoxification is a cellular process

For adherent cells, gently detach cells from the substrate on which they are growing using a suitable dissociation reagent such as Gibco TrypLE reagent

A highly reducing environment is maintained in subcellular compartments, e.g., the cytosol, nucleus, mitochondrial matrix, and peroxisome, to facilitate proper protein folding and activity

Current strategies to combat this include not only modification of the AAV capsid and optimization of the viral genome, but also the use of immunosuppressive therapy [153]
