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They are getting a different, less effective one
Life style choices play an important role in PD progression
Longitudinal and comparative studies provide quantitative examples: in multi-isolate comparisons from China, isolates characterized as high, moderate, and low virulence had reported genome sizes of 309,286 bp, 294,261 bp, and 284,148 bp, respectively, illustrating that genome contraction can be associated with measurable loss of coding potential [72]
Thus, NFT formation may be considered a more reliable diagnostic parameter to judge the clinical severity of AD than amyloid plaque formation (Giannakopoulos et al
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