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these effects were similarly accompanied by an increase in inactivated GSK-3 expression and -catenin activity

it competitively binds to cellular receptors, blocking the body's natural active B6 and potentially inducing a functional deficiency that leads to peripheral neuropathy (nerve tingling and pain)
Regulation of PTP1B via glutathionylation of the active site cysteine 215

doi: 10.1021/jm061379o

2021;67 doi: 10.1016/j.arr.2021.101271
