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After HTx, transient ischemia in portal areas leads to an immediate sinusoidal blood flow cessation (Wilhelm et al., 2004
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The latest evidence supporting the notion that NAFLD is the main factor for incident CKD comes from a recent meta-analysis of 13 studies with a total of 1,222,032 individuals (28.1% with NAFLD)
The mechanism involves positive regulation of the expression of ALDHs and cytoprotective enzymes (e.g
