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Due to its unique structure, 4-HNE stands out among lipid peroxidation products for its intermediate molecular size and high bioactivity, making it a focal point of interest in chronic pathological conditions such as diabetes (Table 1)

These metabolic biomarkers exhibit incremental predictive power when integrated with traditional risk assessment tools like the FRS and SCORE2 systems, as evidenced by net reclassification improvements exceeding 15% in meta-analyses involving over 10,000 participants

Release of Ca2+ from the endoplasmic reticulum is not the mechanism for bile acid-induced cholestasis and hepatotoxicity in the intact rat liver

b , Control or CSA KO cells expressing INTS12-Flag or not (-) were either untreated or treated with UV irradiation (20 J/m2, 1 h recovery)

Keighron C, Lyons CJ, Creane M, OBrien T, Liew A