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The inner-membrane metalloprotease OMA1, which contains a conserved HEXXH zinc-binding motif, cleaves OPA1 to regulate mitochondrial fusion, cristae organization and stress-responsive remodeling of the organelle 84

47 studies were excluded as they did not measure GSH in whole blood, plasma, or serum

The exploration of enterohepatic circulation has confirmed that gut microbiota dysbiosis is closely related to the progression of NAFLD, which not only manifested in the great changes in the gut microbiota diversity and abundance in NAFLD patients compared with healthy subjects but also reflected that gut microbiota disrupted the inflammatory balance and glucose and lipid metabolism through intestinal metabolites (57), as shown in Figure 2

Zauner, J., Hartmeyer, S

The plant-derived compound brusatol also decreases NRF2 protein levels (Ren et al., 2011), and use of any of these compounds improves sensitivity to chemotherapeutics such as cisplatin and gemcitabine