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Under physiological conditions, ROS are produced in a controlled manner by mitochondria, NOXs, and other enzyme systems, and are strictly regulated by antioxidant defenses [540,541,542]

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In particularly, the delivery of microparticles via inhalation is becoming an area of remarkable interest for researchers in the field of respiratory medicine [153]

Activin A, a member of the TGF- superfamily was thought to be involved in the pathogenesis of UF by increasing the ECM components, such as versican, fibronectin, and collagen 1A1, at least in part through activating the Smad-2/3 and p38-MAPK signaling pathway (Islam et al., 2014

Biomarkers 1997