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NFB is the key transcriptional regulator of many pro-inflammatory cytokines, adhesion molecules, chemokines, growth factors and other mediators of inflammation, as tumour necrosis factor (TNF), interleukins 1 (IL-1), 6 (IL-6), and 12 (IL-12), promotes cellular proliferation and protects against apoptosis providing a mechanism that determines chronic inflammation

Elevated intracellular GSH levels represent both a barrier to conventional therapies and an opportunity to design redox-responsive drug delivery systems

Several compounds outperformed PZQs efficacy against adult and juvenile worms

Future research can develop precise delivery systems and combination therapies to optimize therapeutic windows