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If drawing takes noticeably long with a 31-gauge needle, stepping down to 29 gauge eliminates the issue without significantly increasing discomfort
EelderinkCKremerDRiphagenIJKnobbeTJSchurgersLJPaschAet alEffect of vitamin K supplementation on serum calcification propensity and arterial stiffness in vitamin K-deficient kidney transplant recipients: a double-blind, randomized, placebo-controlled clinical trial

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They are easy targets of mold, especially if stored in poorly ventilated areas

doi: 10.1073/pnas.1200012109 54 MurphyJMCzabotarPEHildebrandJMLucetISZhangJGAlvarez-DiazSet al