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Biochemically, different structures are grouped together under B complex on the basis of their natural occurrence in same type of food and solubility in water

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In the CNS, thiamine deficiency can lead to Wernickes encephalopathy, characterized by nystagmus, ophthalmoplegia, mental status changes, and unsteady stance and gait, due to apoptotic cell death in sensitive brain areas, mainly areas with high metabolic requirement, causing symmetrically distributed lesions among structures such as the third and fourth ventricles, besides dorsomedial thalamus (, , )

In the United States, neither peptide has received approval from the Food and Drug Administration (FDA) for human therapeutic use as prescription medications