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At least one third of the bile flow is driven osmotically by the amount of hepatic glutathione excreted into canalicular spaces

Rarely, severe cases require liver transplantation.

Mitochondrial dysfunction has been linked to redox imbalance and excessive production of reactive oxygen species (ROS), which disrupt homeostasis and damage both mitochondrial and nuclear DNA, thereby promoting amyloid- accumulation and cognitive decline

Not for human or veterinary consumption

Notably, sex-specific differences have been observed, with female mice showing greater susceptibility to Nrf2 deficiency, potentially due to interactions with estrogen signaling