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The preclinical evidence is robust, consistent, and mechanistically plausible, but the gap between rat sciatic nerve transection models and human diabetic neuropathy is significant
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Studies have examined its effects on fibroblast activity, extracellular matrix remodeling, antioxidant enzyme expression, and angiogenesis-related signaling pathways
Research involving KPV has often focused on inflammatory signaling pathways and cellular regulatory mechanisms
