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Gemcitabine and mitomycin induced autophagy regulates cancer stem cell pool in urothelial carcinoma cells

In addition, activation of the NADPH oxidase is linked to changes in the structure and function of cerebral arterioles that are associated with small vessel disease [49], and to angiotensin II-dependent activation of the enzymatic complex that increased oxidative stress and hypertension in both rats and endothelial cells [43]

This temporal dissociation suggests that early microglial activation, acting in a neuroprotective fashion, may serve a compensatory or protective role, potentially delaying the onset of clinical symptoms [468]

10.1016/j.biopsych.2009.09.025 Biol