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Rats were treated once daily with embelin (0.3 mg/kg, 0.6 mg/kg, 1.2 mg/kg) and donepezil (1 mg/kg) intraperitoneally (i.p.) for 17 days

As the surface characteristics are primarily responsible for the toxicity of the NPs, modification of surface chemistry and properties has been reported to be one of the most common devised strategies to mitigate NP toxicity (Figure 3) ( FIGURE 3 Surface coating is one of the most popular surface modification strategies to reduce the potential toxicity of NPs, which is reversible by non-covalent modification (Hwang et al., 2018)

These results may provide new ways for designing novel antifibrotic therapies for CsA-induced gingival growth by targeting Snail [35]