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However, issues such as drug resistance and associated side effects have significantly restricted the clinical application of these treatments

A meta-analysis by Raoufi et al

(2024) 115:T7346

Heparin/N-acetylcystine [corrected] nebulization in children with massive burn injury and smoke-inhalation injury results in a significant decrease in incidence of reintubation for progressive pulmonary failure and a reduction in mortality (Class III)

Keep in mind that just because you have an MTHFR mutation doesn't mean that you're going to experience under or overmethylation
