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In the initial stage, curcumin promotes programmed cell death of inflammatory cells, hinders the transcription factor NF-B, decreases cytokine production (tumor necrosis factor-alpha (TNF-) and interleukin (IL)-1), and lowers reactive oxygen species (ROS) levels (287)

Protect from light exposure throughout storage and use

D9542, Sigma Aldrich, Saint Louis, MO, USA)

As well as aromatic and heterocyclic compounds, proteins such as histidine, tyrosine, tyriptophane and phenylalanine posses affinity to transition metals which form complexes with compounds rich in electrons [25,27]

by adjusting pressure, temperature, and the use of co-solvents such as ethanol or water, it can be optimized for higher purity and targeted extraction of diverse phenolic compounds (59)